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Renal transplantation is a lifesaving intervention in end-stage renal disease (ESRD) patients. Here we take you through the key steps in a kidney transplant, from donor selection to ureteric anastomosis.
Step 1: Donor Selection
The initial and most important task of conducting a renal transplant is to find an appropriate donor kidney. There are two categories of donors:
- Live Donor: In India, live donor transplantation is the most common technique. A living individual willingly donates a kidney to the recipient. The donor nephrectomy (removal of the kidney) may be performed open or laparoscopically. Laparoscopic nephrectomy is favored because it is minimally invasive, resulting in faster recovery and fewer complications.
- Cadaveric Donor: A cadaveric kidney is obtained from a brain-dead donor. Cadaveric transplants entail the retrieval of more than one organ, which is not the case with live donation. This is practiced to a lesser extent in India because of the lack of an established cadaveric organ donation program.
Step 2: Bench Dissection
- After obtaining the kidney, it receives a bench dissection before transplantation. This entails:
- Stripping off fat and fibrous tissue.
- Recognizing and separating out the renal artery and vein.
- Perfusing the kidney with custom preservation solutions to remove any lingering blood and guarantee viability before transplantation.
Step 3: Implantation in the Recipient
The recipient receives an open renal transplant, usually in the iliac fossa instead of the kidneys’ initial anatomical site. This is known as heterotopic transplantation, in which the kidney is transplanted to a site other than where it originally existed within the body.
Surgical Incision and Preparation
- The surgeon performs a hockey-stick incision in the lower abdomen.
- The peritoneum is retracted, and dissection is carried out in the retroperitoneal space.
- The iliac vessels are exposed, and overlying lymphatic tissues are dissected to prepare the vascular bed.
Step 4: Vascular Anastomosis
The transplanted kidney must be anastomosed to the recipient’s blood vessels to function properly. The anastomosis (surgical connection) is carried out as follows:
Arterial Anastomosis
- The renal artery is anastomosed to either the external iliac artery or the internal iliac artery:
- Internal Iliac Artery: End-to-end anastomosis.
- External Iliac Artery: End-to-side anastomosis.
- The selection of the artery is based on the vascular anatomy and health of the recipient’s vessels.
Venous Anastomosis
- The renal vein is anastomosed to the external iliac vein with an end-to-side anastomosis.
These vascular anastomoses provide sufficient blood supply to the transplanted kidney.
Step 5: Ureteric Anastomosis
The transplanted kidney’s ureter has to be anastomosed to the recipient’s bladder in order to facilitate drainage of urine. The best method for this is the Modified Lich-Gregoir technique:
- A small cut is made in the bladder wall.
- The detrusor muscle is dissected carefully, and the ureter is implanted so that reflux (urine backflow) is avoided.
- The ureter is fixed in position to maintain optimal function and avoid complications such as leakage or obstruction.
Final Steps and Post-Transplant Care
Following successful implantation, the wound is closed, and the patient is carefully observed for evidence of organ rejection, infection, or vascular or ureteric anastomotic complications. Immunosuppressive therapy is commenced to avoid rejection, guaranteeing the survival of the transplanted kidney.
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